• Pueraria Mirifica Results

    Pueraria Mirifica Results, what to expect. In this article you will find facts about the biological chemistry of Pueraria Mirifica. Pueraria Mirifica’s phytoestrogen chemical components act on a myriad of tissues in the body in a similar way- they all activate and mimic estrogen via the two estrogen receptors (alpha and beta). Numerous types of tissues in the body contain the estrogen receptors, with the most in the female reproductive system, which includes breast, uterine, ovarian, and oviduct tissues. The brain, bones, liver and heart also contain estrogen receptors and respond to estrogen. The tissues where the estrogen receptors do not exist, Pueraria Mirifica has no influence on them.

    Pueraria Mirifica’s primary active ingredients, deoxymiroestrol and miroestrol, bind the estrogen receptors with a very strong affinity. In fact, at certain concentrations, it was found to bind the estrogen receptors even more than estradiol, which is the strongest estrogen hormone the human body produces (estrogen is the common term encompassing three hormones: estradiol, estrone and estriol). Once bound to the estrogen receptor, the phytoestrogens must activate the estrogenic pathway that results in the physical changes associated with an increased amount of estrogen (or phytoestrogens mimicking estrogen activity in the case of Pueraria Mirifica). Binding alone does not determine the activation of this pathway and certain compounds can actually inhibit the estrogen pathway. However, the phytoestrogens in Pueraria Mirifica have been proven to activate the estrogen pathway very strongly.

    Research from the UK published in the Journal of Steroid Biochemistry and Molecular Biology found that deoxymiroestrol and miroestrol have “potent estrogenic activity in every assay in vitro and… also reported in vivo assays over several decades.” Not only does deoxymiroestrol and miroestrol tightly bind the estrogen receptor, they activate the same host of genes that estrogen activates. In a comparative study of eight phytoestrogens deoxymiroestrol and miroestrol were ranked first and second in terms of ability to activate the estrogen pathway (after estradiol). After that, coumestrol and genistein, phytoestrogens also found in Pueraria Mirifica, came in fourth and fifth respectively. Below is a diagram of how estrogen and phytoestrogens trigger gene activation in general:


    So what does all this binding and gene activation do? It depends where the cells with the estrogen receptors are. For example, cells in the liver respond to estrogen by increasing the amount of HDL (good cholesterol) and decreasing the amount of LDL (bad cholesterol) produced in the liver. Thus estrogen has been shown to lower the risk of heart disease. Studies on Pueraria Mirifica and heart disease have not been conducted to show a relationship, yet it is not improbable Pueraria Mirifica could reduce the risk of heart disease. Below is a diagram of how estrogen triggers gene activation in the liver:


    In the brain, estrogen helps maintain body temperature and is speculated to delay memory loss. In bones, estrogen aids in the preservation of bone density. In the vagina, estrogen helps maintain a lubricated and thick vaginal lining. Since Pueraria Mirifica phytoestrogens mimic estrogen, many of the beneficial effects of estrogen are seen in people that use Pueraria Mirifica.

    For example, Pueraria Mirifica has been proven to reduce hot flashes during menopause. One study states, “Pueraria Mirifica… can alleviate the climacteric symptoms in perimenopausal women.”“Climacteric symptoms,” is a scientific term for hot flashes. Other studies have shown that Pueraria Mirifica can improve bone density, which declines in women post-menopause. Also, Pueraria Mirifica was shown to increase natural vaginal lubrication.

    This is not surprising because the onset of menopause is characterized by changes in the amount of estrogen naturally produced in the body. Women post-menopause have decreased levels of estrogen in them and that results in the symptoms discussed above (hot flashes, decreased bone density, less vaginal lubrication, etc.). Thus Pueraria Mirifica’s estrogenic activity can replace that diminished naturally from menopause. No wonder Pueraria Mirifica has been characterized as the “Fountain of Youth.”

    Does this mean Pueraria Mirifica should only be taken by women going through or post-menopause? No, because the beneficial effects of estrogen extend to women before they’ve gone through menopause. For example, in the breast, the main effect of estrogen is to cause cells to grow and divide, also known as cell proliferation. Specifically, estrogen pathway activation promotes cell proliferation around the mammary glands of the breast. More on this topic and other beneficial properties of Pueraria Mirifica will be discussed on the pages to follow.